CORDIS Project
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This project investigates the innate immune response to HIV-1 in dendritic cells, focusing on how the virus interacts with host factors to activate immune responses. By understanding these mechanisms, the research aims to uncover new strategies for enhancing immune control of HIV-1 infection.
Our goal is to understand the innate immune response to HIV-1.
We have found that a cryptic innate immune response to HIV-1 exists in dendritic cells (DC).
This response is normally inactive because HIV-1 is unable to infect DC.
We have used the Vpx protein found in other lentiviruses to render DC susceptible to HIV-1 infection.
The resulting innate response to HIV-1 requires an interaction between de novo synthesized Capsid and cellular Cyclophilin A.
This interaction leads to the IRF-3-dependa…
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