CORDIS Project
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This project investigates the relationship between torsional stress in DNA, the enzyme DNA Topoisomerase I, and the formation of R loops, which are crucial for genome stability. It aims to develop novel assays to explore these interactions in human cells.
When DNA is transcribed or replicated, torsional stress accumulates on the double helix.
This tension must be dissipated by spreading it along the DNA fiber, or it must be removed altogether.
One of the main factors responsible for the removal of such stress is DNA Topoisomerase I (Top1), an important target of cancer chemotherapy.
When Top1 activity is lost, torsional stress accumulates on transcriptionally active genes and can lead to the formation of non-canonical DNA/RNA hybrid structures ca…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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