CORDIS Project
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This project aims to identify the genes involved in amino acid regulation of the TOR kinase, a key player in cell growth and metabolism. By using a genome-wide screening approach, it seeks to uncover new factors that could lead to advancements in cancer and metabolic disease treatments.
The kinase TOR is a key regulator of cell growth and organismal metabolism in animals.
Consequently, the correct regulationof TOR activity is important both for normal development and for disease.
For instance, TOR is hyperactivated in almost allhuman cancers, and reduced TOR activity is associated with leanness and resistance to obesity. TOR activity is regulatedby a number of inputs including, importantly, amino acids.
Indeed, nutritional amino-acid overload in humans is thought topromote insu…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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