CORDIS Project
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This project investigates the role of topoisomerase II beta in the epigenetic regulation of neuronal differentiation. It aims to understand how this enzyme influences gene expression and chromatin organization during the development of nerve cells.
Transcriptional regulation defines the identity of pluripotent and differentiated cells.
DNA Topoisomerases are enzymes that catalyze the unlinking of the DNA strands by making transient DNA strand breaks and allowing the DNA to rotate around these breaks, a process essential for DNA replication, transcription, chromosome condensation and segregation (Champoux, 2001).
A mammalian-specific distinct type of topoisomerase, topoisomerase II beta (TopIIβ), is only abundantly expressed in terminally d…
Novartis Forschungsstiftung
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