CORDIS Project
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The project investigates the molecular interactions between Topoisomerase III and the RMI1 protein in yeast, focusing on their role in DNA replication and stability. By employing biochemical and crystallographic techniques, it aims to elucidate how these proteins contribute to genome integrity during homologous recombi…
The eukaryotic Topoisomerase3 (TopIII) belongs to the replicative machinery present at the replication fork.
TopIII is a type 1 enzyme whose activity is known to unlink the DNA single strand catenanes as shown by the crystal structure of the E. coli Topoisomerase III solved in 2001.
The TopIII propensity to solve DNA topological problems and to complete homologous recombination events during replication made of it a key component in genome stability and integrity.
The atomic mechanisms of TopIII…
Novartis Forschungsstiftung
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