CORDIS Project
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The TopBMemory project investigates how the site of initial exposure to antigens influences immune memory in human memory B cells. It aims to understand the differences between mucosal and systemic immunity and how subsequent exposures can reprogram immune responses, ultimately contributing to improved vaccine and ther…
The novel COVID-19 vaccines have effectively reduced morbidity and mortality but unexpectedly failed to provide long-lasting sterilizing immunity.
While specific serum antibody (Ab) titers were durable, local upper respiratory tract (URT) mucosal Ab responses were surprisingly short-lived.
This shows both our lack of and need for a deeper understanding of URT mucosal immunity and its distinctions from systemic immunity.
My proposal is designed to answer two key questions arising from this:
How d…
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