CORDIS Project
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This project investigates the role of the bone marrow environment in the progression of multiple myeloma from its precursor state, monoclonal gammopathy of undetermined significance. By analyzing bone marrow stromal cells from patients and healthy individuals, the research aims to uncover factors that influence tumor g…
Multiple myeloma (MM), the second most common hematological malignancies, is characterized by an expansion of malignant plasma cells (PCs) in the bone marrow (BM).
Despite the development of novel therapies, MM remains an incurable disease with a 5-7 year survival expectancy. MM is usually proceeded by an asymptomatic premalignant state of clonal PC expansion, i.e. MGUS.
Progression of MGUS to MM is a multistep process, which is partially dependent on the acquisition of genetic alterations.
Howe…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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