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The TomoFind project enhances cryo-electron tomography by developing deep learning tools and refining data acquisition methods to improve the identification of biomolecular structures in three-dimensional cellular contexts. This interdisciplinary effort aims to advance structural biology research through innovative alg…
Cryo-electron tomography (cryo-ET) revolutionises cellular structure visualisation, but extracting biological insights is often hindered by limitations of subtomogram averaging (STA).
With AlphaFold2's recent breakthroughs in structure prediction, identifying known structures in their 3D cellular context is often more important than structure determination by STA.
The TomoFind project aims to significantly improve our ability to identify biomolecular structures within tomographic reconstructions…
UNITED KINGDOM RESEARCH AND INNOVATION
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