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The TOLKEDA project investigates a novel molecular mechanism involving neurotrophins and receptors that influence brain plasticity and degeneration. By studying these interactions in Drosophila models, the project aims to uncover potential therapeutic targets for neurodegenerative diseases like Parkinson's.
The aim of TOLKEDA is to test the hypothesis that a novel molecular mechanism linking neurotrophins, Tolls and truncated Trk-like receptors modulates structural brain plasticity vs. neurodegeneration.
The brain changes throughout life: structural plasticity drives generation of neurites, neurons and synapses to adapt and learn; their elimination maintains homeostasis, but causes neurodegeneration in ageing and disease.
Brain disease is the major health burden in Europe, costing more than cancer…
THE UNIVERSITY OF BIRMINGHAM
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