CORDIS Project
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This project aims to catalog and analyze long non-protein-coding RNAs in humans, particularly those expressed in the brain. It focuses on understanding their evolutionary emergence and potential role in regulating nearby protein-coding genes.
Genome-wide transcription maps of different model species [1-5] reveal an unforeseen number of transcribed DNA segments lacking protein-coding potential [1, 2, 4, 5].
These non-protein-coding RNAs (ncRNAs) are frequently expressed in the brain [6] and, although generally acknowledged as functionally relevant, the biological role of most long ncRNAs remains unclear mainly due to the lack of prediction tools and testable hypotheses.
Recent work in the host institution indicates that some brain-exp…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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