CORDIS Project
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This project examines transcriptional mutagenesis and its impact on the tumor suppressor protein p53. By creating specific DNA damage in cells, it aims to understand how mutations affect cell cycle regulation and responses to toxic substances.
The process of misincorporation of incorrect bases into the nascent RNA as a result of DNA-lesion bypass by RNA polymerases during transcription is referred to as transcriptional mutagenesis (TM).
Although this has been shown to alter the subsequent proteins function, the relative importance of TM in human health is virtually untouched. I propose to study the cellular effects and biological significance of TM using the tumor suppressor protein p53 as probe.
The choice of p53 is based on its role…
KAROLINSKA INSTITUTET
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