CORDIS Project
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This project investigates the role of the poleta polymerase in DNA repair mechanisms related to xeroderma pigmentosum variant, a genetic disorder that increases skin cancer risk. It aims to uncover how poleta's function is regulated and its potential as a therapeutic target.
Xeroderma pigmentosum variant (XPV) is an autosomal recessive genetic disorder that results in enhancced predisposition to skin cancers. XPV results from a defect in the translesion synthesis (TLS) polymerase poleta. TLS allows bypass of unrepaired damage permitting completion of replication.
Poleta is phosphorylated and ubiquitinated and can interact with ubiquitin and SUMO, two post-translational modifications that are important in a number of DNA repair pathways, via multiple domains.
Mutants…
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