CORDIS Project
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This project investigates the role of tertiary lymphoid structures in cancer prognosis and response to immunotherapy. It aims to develop therapies for inducing these structures and to understand the function of B cells in the tumor microenvironment.
Tertiary lymphoid structures (TLS) are ectopically generated lymphoid structures with some level of cellular organisation similar to the secondary lymphoid organs, characterised by having a B-cell zone adjacent to a T-cell zone.
The presence of tumor immune infiltrates, especially in the form of TLS, has been linked to a better cancer prognosis in different types of tumor and improved response to immune checkpoint inhibitors (ICB).
However, interestingly, not all the patients develop TLS and the…
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
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