CORDIS Project
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This project aims to enhance adoptive T cell therapies for solid tumors by engineering T cells with switch receptors that respond to innate immune signals. By improving T cell function within the tumor microenvironment, the research seeks to increase the effectiveness of these therapies against a wider range of cancers…
Immunotherapy, particularly adoptive T cell therapies (ACT), has revolutionized cancer treatment, providing significant benefits to patients with haematological malignancies.
Despite these successes, their effectiveness against solid tumors remains limited. A major unaddressed obstacle in treating solid malignancies with ACT is the suppression of T cells within the tumor microenvironment (TME), which hampers their sustained activity against tumor cells.
Thus, there is a critical need to optimize…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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