CORDIS Project
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This project investigates the role of serotonin receptors, specifically 5-HT2C, in major depression. It aims to understand the feedback mechanisms in the brain related to these receptors and their response to stress and treatment, potentially leading to new therapeutic strategies.
Despite the devastating impact of major depression on society, our knowledge of the brain mechanisms of depression is such that individuals at risk cannot be reliably detected, over a third of patients are refractory to treatment, and
patients are being managed on a daily basis with antidepressant strategies without the guidance of a satisfactory explanation of their mechanisms of action.The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) is critically important
for maintaining mood in vu…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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