CORDIS Project
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This project focuses on enhancing the effectiveness of adoptive T cell therapies for cancer treatment. It aims to improve T cell fitness through metabolic interventions and machine-learning techniques, ultimately increasing the success rate of personalized therapies for solid tumors.
Adoptive T cell therapies (ACTs) are emerging as a promising strategy to treat cancer.
Tumor-infiltrating lymphocytes (TILs) are expanded ex vivo, selected for recognition of neoantigens, further expanded and then infused back into patients.
This procedure requires extensive culturing and expansion of TILs during which many T cell clonotypes are lost.
As tumor-reactive TILs are often exhausted and tend to be overgrown by functional, non-specific T cells in culture, the chance to identify potent…
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
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