CORDIS Project
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The TIKKS project aims to investigate the presence and distribution of kinins in various tissues using advanced mass spectrometric imaging techniques. By focusing on malignant tissues and cardiovascular diseases, the project seeks to enhance understanding of the kallikrein-kinin system, which could lead to the discover…
Cardiovascular diseases, cancer, and sepsis are the leading causes of death worldwide.
In all of them, a strong involvement of the endogenous kallikrein-kinin system (KKS) is postulated.
However, the KKS is only rudimentarily understood, which is also reflected by the large proportion of developed drugs showing insufficient efficacy.
The KKS is a 2-arm cascade that is present in both the blood as well as the tissue and its actions are mediated by the so-called kinins.
Comprehensive insight into…
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
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United States, Houston Tx
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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