CORDIS Project
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The TiGER project investigates how the giant protein titin influences gene expression and chromatin structure in heart cells by transmitting mechanical tension to the nucleus. Using human stem cell-derived heart cells, the project aims to understand the role of titin in cardiac health and disease through advanced imagi…
Heart disease is a staggering clinical and public health problem and the leading cause of death for both men and women in Western countries.
The underlying pathomechanism of nearly all aetiologies relates to altered contractility and cardiac tissue tension but also gene expression changes and epigenomic remodelling.
Within the sarcomere, the fundamental contractile unit in striated muscle, the giant protein titin is the major source of cardiac passive tension.
Since sarcomeres are connected to t…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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