CORDIS Project
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This project investigates the role of Tie2-expressing monocytes in tumor growth and angiogenesis. By characterizing these cells and their molecular pathways, the research aims to develop targeted therapies for cancer treatment, including gene therapy strategies for delivering interferon-alpha to tumors.
Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis.
We contributed to this concept by showing that Tie2-expressing monocytes (TEMs) have a requisite role in this process.
Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models.
Yet, little is known of the biological bases of TEMs activity in tumors.
Building upon my previous studies, I will provide a thorough characterization of the precise identity of TEMs and of thei…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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