CORDIS Project
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This project investigates the role of glycoprotein I-IX-V in platelet adhesion and aggregation, focusing on how its expression affects platelet reactivity and traction forces. By developing a high-throughput platform for single-cell measurements, it aims to enhance understanding of platelet behavior in cardiovascular d…
Platelet-mediated thrombosis is a major cause of death and disability globally.
Thrombosis occurs when platelets adhere and aggregate.
In the arterial circulation initial platelet adhesion occurs when the platelet glycoprotein (GP) I-IX-V receptor binds to von Willebrand Factor (vWF).
Increased or decreased expression levels of GPIb are associated with increased risk for cardiovascular events and bleeding respectively.
The expression of GPIb varies significantly among healthy subjects.
The pro…
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