CORDIS Project
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This project investigates the role of cancer stem cells and their signaling networks in breast cancer metastasis and treatment resistance. By utilizing advanced mass cytometry, it aims to create detailed models of these networks at the single-cell level, correlating them with tumor microenvironments and genetic factors…
Tumor metastases, relapse, and resistance to therapy are the main causes of death in cancer patients.
Cancer stem cells (CSCs) drive cancer growth, are likely responsible for cancer reoccurrence, and provide the potential to colonize a metastatic site. A cell plasticity process called epithelial-mesenchymal transition (EMT) generates CSCs from epithelial cancer cells and simultaneously equips these cells with motility and invasiveness, features prerequisite for metastasis.
Consequently, therapeu…
University of Zurich
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