CORDIS Project
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This project explores the use of thiophenylalanine in peptide and protein chemistry to enhance the synthesis of biomolecules. By developing a mild method for its incorporation, it aims to improve techniques for peptide stapling and bioconjugation, which could significantly advance chemical biology applications.
Chemoselective functionalisation of peptides and bio-conjugation of proteins has led to great advances in the synthesis of clinically relevant biomolecules and our understanding of cellular processes.
Thiophenylalanine represents an interesting handle owing to the increased acidity of the aryl thiol which would mean a higher percentage of reactive thiolate would persist even at physiological pH, allowing chemoselective reactions to be performed.
Despite the interesting qualities of the residue,…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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