CORDIS Project
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This project investigates the mechanisms behind tumor evolution and heterogeneity in cancer. By developing new animal models, it aims to understand how genomic instability affects treatment resistance and to identify novel therapeutic targets.
SummaryThe majority of metastastic solid tumours remain incurable.
In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH).
Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome.
However, despite increasing knowledge of tumour diversity, there is limited insight into the mechanisms driving genomic instability and ITH or the processes that…
THE FRANCIS CRICK INSTITUTE LIMITED
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LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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