CORDIS Project
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This research investigates the role of temperature in the development of Alzheimer’s disease by examining how heat affects the processing of proteins involved in the disease. It aims to uncover new therapeutic targets by studying the relationship between neuronal thermogenesis and protein stability.
Alzheimer’s disease (AD) is the leading cause of dementia, yet current therapies provide only modest benefit.
Mutations in presenilin (PSEN1/2), the catalytic subunit of γ-secretase (GSEC), cause familial AD by destabilizing the GSEC–APP/C99 complex and shifting processing toward longer, aggregation-prone Aβ42/43 peptides.
Importantly, even wild-type GSEC produces small amounts of these species, suggesting that subtle complex destabilization also contributes to sporadic AD.
This raise a critical…
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