CORDIS Project
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This project explores the role of protein misfolding in neurodegenerative diseases, particularly focusing on the unfolded protein response in neurons. It aims to investigate how translational failure contributes to diseases like Alzheimer's and Parkinson's, and to identify potential intervention strategies.
This proposal aims to increase our understanding of the role of translational failure in human neurodegenerative diseases.
We recently discovered the mechanism by which protein misfolding leads to neurodegeneration in prion disease.
The pathway involved is a generic cellular pathway, a branch of the unfolded protein response (UPR) that controls protein synthesis at the level of initiation of translation.
Rising levels of misfolded prion protein cause sustained over-activation of the PERK-eIF2α…
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