CORDIS Project
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The project investigates stress granule proteins as novel regulators of mTOR signaling in cancer, particularly breast cancer. By employing advanced techniques, it aims to characterize the interactions and mechanisms of these proteins in metabolic signaling, linking them to cancer prognosis and treatment response.
mTOR kinase is an oncogenic master regulator of metabolism and cell growth and is known to reside in two multiprotein complexes.
Upon stress, mTOR is inhibited by stress granules (SGs), which recruit mRNAs and signaling factors to promote survival.
Current work largely addresses the functions of SG proteins under stress, focusing on their RNA binding properties and SG assembly.
However, non-stress functions are emerging. I propose that SG proteins have prime functions in mTOR signaling at metabo…
UNIVERSITAETSKLINIKUM ESSEN
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Austria, Innsbruck
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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