CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of GATA3, a transcription factor, in the adult kidney and its involvement in kidney diseases like glomerulonephritis. It aims to understand GATA3's expression patterns, its impact on disease susceptibility, and the molecular pathways it regulates, particularly the Wnt/beta-catenin pat…
Mutations in GATA3, a dual zinc-finger transcription factor, cause the autosomal dominant hypoparathyroidism, deafness, renal dysplasia (HDR) syndrome, and down-regulation of GATA3 results in clear cell renal cell carcinoma.
The renal abnormalities in HDR patients consist of cysts, renal aplasia/hypoplasia, mesangioproliferative glomerulonephritis, and vesicoureteral reflux.
In the developing kidney, GATA3 is expressed in the ureteric bud along the branching process that gives rise to the colle…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
