CORDIS Project
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This project focuses on understanding the development of limb skeletons in vertebrates by analyzing signaling pathways in mouse limb buds. It aims to clarify how specific signals influence the formation of digit identities and explore their implications for tissue engineering in regenerative medicine.
The limb bud is a system of paradigmatic value to analyze vertebrate organogenesis.
One major question is when and how the chondrogenic progenitors of the limb skeleton are determined.
Recent studies suggest that digit identities are only fixed during advanced autopod development by BMP signal transduction.
Here, I propose an in-depth analysis of the underlying signaling systems using mouse limb buds to gain insight into the requirement of Smad4-dependent and independent BMP signaling for chond…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
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