CORDIS Project
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This project investigates how the circadian clock and sleep influence synaptic plasticity and behavior using zebrafish. By employing advanced imaging techniques, it aims to identify specific neuronal circuits that regulate these processes, contributing to our understanding of sleep disorders and memory functions.
Alterations in endogenous circadian rhythm and debilitating sleep disorders represent an unsolved medical problem.
The circadian clock regulates the sleep/wake cycle and is complemented by homeostatic sleep pressure factors.
Surprisingly, why we sleep and how the clock synchronizes rhythmic behavior, remain a mystery.
Intriguing hypotheses suggest that the role of sleep is to maintain synaptic homeostasis or to reactivate specific circuits that are important to memory and learning.
Also, it is p…
BAR ILAN UNIVERSITY
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