CORDIS Project
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This project investigates how the uptake of foreign DNA influences the evolution and spread of Streptococcus pneumoniae, a significant human pathogen. It aims to understand the mechanisms of recombination that contribute to drug resistance and vaccine evasion, using a combination of microbiology, immunology, and epidem…
The aim of this project is to improve our understanding of the role of recombination (uptake and incorporation of foreign DNA) for the evolution and epidemiology of the major human bacterial pathogen Streptococcus pneumoniae, also known as the pneumococcus.
There is an increasing appreciation of the public health significance of recombination in S. pneumoniae, where recombination has enabled major drug-resistant lineages to rapidly evade new conjugate vaccines.
Here, I propose to investigate the…
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