CORDIS Project
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This project aims to create mouse models to study the role of the Rab7 protein in axonal transport and its connection to neurodegenerative diseases. By impairing Rab7 activity, researchers hope to uncover its function in neuron health and disease progression.
Neurons are highly polarized cells that depend on anterograde and retrograde transport for survival, differentiation and maintenance of their morphology.
Recently, impairment of axonal trafficking has been implicated as a causative agent in a number of human neurodegenerative disorders, such as Charcot-Marie-Tooth type 2B (CMT2B) neuropathy. CMT2B is characterized by the selective loss of motor and sensory neurons due to mutations in the small GTPase Rab7.
Rab7 is a key component of the endocyti…
CANCER RESEARCH UK LBG
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