CORDIS Project
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This project examines the role of Polycomb-group proteins in breast cancer stem cells. By using genetically modified mice, it aims to understand how these proteins contribute to tumor maintenance and explore potential targeted therapies.
Breast cancer is the most common malignancy of women in developed nations.
Approximately 1 in 9 women will be diagnosed with breast cancer and many will receive chemotherapy and achieve long-term cancer control.
However, in approximately one-third of these women, cancer will recur.
This is thought to be due to the presence of chemotherapy-resistant ‘breast cancer stem cells’.
Two Polycomb-group proteins, Bmi1 and Ezh2, are frequently over-expressed in breast cancer, suggesting that these epigene…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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