CORDIS Project
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This project investigates the immune response to the gut fungus Candida albicans, focusing on the Th17 cell response. It aims to understand the early immune mechanisms involved in antifungal defense and the regulation of fungal homeostasis.
Intestinal fungi are an important component of the microbiome and their homeostasis/dysbiosis constantly shapes the immune responses.
The human commensal fungus Candida albicans colonizes the gut of 40-80% of individuals.
However, life-threatening infections caused by this fungus are relatively rare since the unwinding of its pathogenic potential is kept in check by the immune system.
In line with this, immunodeficient patients suffer often from Candidiasis, which is typically difficult to treat…
UNIVERZITA KARLOVA
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