CORDIS Project
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This project investigates the role of degradation pathways in the differentiation of haematopoietic stem cells. By studying how these pathways influence cell fate and maintenance, the research aims to identify potential therapeutic targets for regenerative medicine.
The haematopoietic system relies on the potential of haematopoietic stem cells (HSCs) to self-renew and differentiate into all lineages of mature blood cells, and is a reference model to study differentiation hierarchies.
Cell fate determination results from different layers of regulation, including transcriptional, translational, epigenetic, metabolic, and cell biological changes.
Degradation pathways, such as autophagy and the proteasome, play mechanistically relevant roles that in principle m…
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