CORDIS Project
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This research focuses on the role of Chk1, a protein involved in DNA damage response, in hair follicle stem cells. It aims to understand how the absence of Chk1 affects cell behavior and could lead to tumor formation.
We have found that the ablation of Chk1, a serine-threonine kinase that is activated after DNA damage, strongly reduced the formation of chemically (DMBA/TPA) induced skin tumours, thus suggesting a role of this protein in hair follicle stem cells population, from which tumours are thought to arise.
We have observed that deletion of Chk1 causes cell proliferation, DNA damage, and apoptosis within the hair follicle, however the populations affected and the order of events in individual cells have…
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