CORDIS Project
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This project investigates the role of the A20 protein in regulating immune responses in asthma. By studying its effects on mast cells and dendritic cells, the project aims to clarify the mechanisms behind allergic inflammation and identify potential therapeutic targets.
Asthma is a chronic inflammatory airway disease in which the transcription factor NF-kB plays a crucial role. NF-kB controls the activation of mast cells and dendritic cells (DC) that contribute to disease pathogenesis.
Activation of NF-kB is tightly regulated by ubiquitination and deubiquitination of signaling intermediates.
Studies in the host laboratory identified several deubiquitinating enzymes like A20 (also known as TNFaip3) and its binding partners to set the tone for NF-kB activation. A…
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