CORDIS Project
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This project investigates the role of nuclear pore complexes in regulating gene expression and transport between the nucleus and cytoplasm. It aims to understand the structure and function of adaptor complexes that link gene positioning to nuclear pores.
Nuclear pore complexes (NPCs) form macromolecular assemblies in the nuclear envelope and mediate bidirectional cargo movement between the nucleus and cytoplasm.
Recent evidence suggests that NPCs are not merely transport channels but act as gene regulators.
Studies in yeast demonstrate that inducible genes can reposition from the nuclear interior to the nuclear periphery upon activation.
At the periphery activated genes engage in physical contacts with nuclear pores.
Targeting and tethering of…
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