CORDIS Project
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This project investigates the molecular mechanisms that enable axon re-extension in neurons after pruning, using Drosophila as a model. It focuses on the role of a specific steroid hormone receptor, HR51, and aims to identify its ligand and other related molecules to enhance our understanding of neuronal regeneration.
Lack of neuronal regeneration following injury such as spinal cord injury is the major cause for poor functional recovery.
It has long been appreciated that young neurons can grow, undergo reorganization and synapse on appropriate targets during development while adult neurons cannot, however the molecular basis of these differences remain unclear.
Studying the molecular mechanisms that regulate axon re-extension following remodeling during development holds the promise to uncover molecular rule…
WEIZMANN INSTITUTE OF SCIENCE
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