CORDIS Project
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This research explores somatic structural variations in cancer genomes, particularly focusing on genomic insertions caused by transposable elements and viruses. It aims to characterize their impact on gene function and cancer development using next-generation sequencing data.
Somatic structural variation (i.e., those structural rearrangements arising in a tumour) is found in almost all cancer genomes studied in detail.
Current next-generation sequencing (NGS) strategies allow the identification of genomic structural variation with an unprecedented base pair resolution, revealing a complex landscape of somatic rearrangements in several cancer types.
The studies carried out so far have focused upon four main types of rearrangement, namely deletions, amplifications, inv…
GENOME RESEARCH LIMITED
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