CORDIS Project
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This project investigates the role of the c-ErbB2 gene in breast cancer, particularly its relationship with stem cells and tumor development. By studying mouse models, the research aims to uncover the origins of HER2-positive tumors and their implications for treatment resistance.
c-ERBB2/HER2 is a gene that is found overexpressed in ~25% of mammary tumours, and defines the molecular signature of one of the breast cancer subtypes: the HER2-positive tumour subtype.
However, the role of the c-ErbB2 tyrosine kinase and the stem cell of origin of HER2-positive breast cancers are poorly understood.
Our project aims to study the relationship between c-ErbB2 function and normal and tumour stem cells, as well as on the origin and development of HER2-positive tumours.
First, we wi…
INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG
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