CORDIS Project
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This project investigates how aging affects the bone marrow environment and its impact on hematopoietic stem cells, which are crucial for blood and immune cell production. By developing a model of the aged bone marrow niche, the project aims to uncover the mechanisms behind the decline in stem cell function associated…
In humans, aging of the hematopoietic system is associated with anaemia, impaired immune responses and increased frequency of myeloid malignancies.
The hematopoietic system is maintained by hematopoietic stem cells (HSCs). HSCs reside in the bone marrow (BM) within specialized niches, where they self-renew and differentiate to produce all blood and immune cells.
In the clinical setting of BM transplantation, HSCs from older donors result in a reduced transplantation success, with a worse level o…
UNIVERSITAET ULM
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