CORDIS Project
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This project investigates the role of B cells in post-myocardial infarction atherosclerosis using advanced genetic and sequencing techniques. By analyzing B cell responses and developing specific antibodies, the research aims to identify new therapeutic targets for preventing cardiovascular disease in patients who have…
Survivors of acute myocardial infarction (MI) are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis.
Nevertheless, mechanistic preclinical studies in atherosclerosis research world-wide are typically conducted in unchallenged (without MI) atherosclerosis-prone mice and thus do not address the specific pathophysiology of post-MI atherosclerotic cardiovascular disease.
We conducted a single-cell RNA sequencing coupled to B cell receptor (BCR) sequencing an…
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