CORDIS Project
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This project investigates chronic visceral pain by examining the structure and function of sensory nerves in the human colon. It aims to identify molecular targets that could be pharmacologically modulated to alleviate pain, bridging basic research with clinical applications in pain management.
Chronic visceral pain (CVP) is one of the most frequent reasons for seeking health care.
Pain can arise from inflammatory disease, but 50% of patients with visceral pain have no diagnostic abnormalities, and are classed as “functional”.
Both types of CVP are poorly understood, but animal studies show that they involve hypersensitivity of visceral sensory nerves, and some of the molecular mechanisms of hypersensitivity are emerging.
We now need a translational program which identifies molecular t…
QUEEN MARY UNIVERSITY OF LONDON
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