CORDIS Project
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This project investigates the mechanisms behind autoimmune skin diseases like psoriasis and atopic dermatitis by analyzing how different types of T helper cells influence skin pathology. Using a mouse model, it aims to understand T cell polarization and its therapeutic manipulation.
Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated.
After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles.
While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent evidence indicates an important pathogenic role for Th17 cells.
However, it is not fully understood why a p…
UNIVERSITATSKLINIKUM HEIDELBERG
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