CORDIS Project
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This project explores the relationship between high cholesterol levels and tendon health, focusing on how cholesterol accumulation affects tendon function. It aims to investigate the underlying mechanisms and potential reversibility of these changes, with implications for orthopedic treatment and rehabilitation.
Musculoskeletal disorders, particularly to the muscle-tendon unit, are a major cause of occupational disability in the European Union.
The link between high cholesterol and poor tendon function has recently been demonstrated by several groups.
However, the underlying pathophysiology of this association remains unknown.
Cholesterol is known to leave the circulation and accumulate in extracellular matrix through interactions between LDL and glycosaminoglycans (GAG).
Tendons are GAG rich in the int…
QUEEN MARY UNIVERSITY OF LONDON
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Canada, Vancouver
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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