CORDIS Project
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This project studies the mechanisms behind allergic asthma by investigating CD4+ T helper type 2 cells in a mouse model. It aims to identify chemokine interactions that influence the migration and retention of these immune cells in the lungs during disease relapses.
Allergic asthma is a disease of airway inflammation caused by an allergic reaction to an antigen.
Pathogenic CD4+ T helper type 2 (Th2) cells in lungs are involved in the initiation and perpetuation of the allergic response in airways of asthmatics and animals.
Mouse models generated by systemic immunization and respiratory tract exposure with inhaled antigen or by adoptive transfer of effector Th2 cells into naive mice develop eosinophilic inflammation, mucus hypersecretion, and airway hyperrea…
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