CORDIS Project
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This project investigates the role of the Nup98-HoxA9 fusion protein in acute myeloid leukemia. It aims to utilize advanced imaging and microfluidics to study its structure and function, enhancing understanding of its contribution to gene regulation and leukemogenesis.
Nup98 is a mobile nucleoporin that localizes both at the nuclear pore complex and within the nucleus.
Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners.
Nup98-HoxA9 (NHA9), a fusion between phenylalanine-glycine-rich (FG-rich) region of Nup98 and the homeobox transcription factor (TF) HoxA9, is one of the most frequent Nup98-fusion associated with acute myeloid leukemia.
The physiological role of NHA9 in hematopoietic development has been gradually e…
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