CORDIS Project
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This project investigates the role of Follicular Helper T cells in developing long-lasting immune responses, particularly focusing on how these cells can be retained in lymphoid tissues. By understanding their differentiation and retention mechanisms, the project aims to enhance vaccine design for better B cell immunit…
An effective immune response relies on the helper T cell (TH) regulated development of high-affinity B cell memory.
Follicular Helper T (TFH) cells are the critical regulators of the B cell response.
Until recently, TFH cells were considered fully differentiated cells prone to apoptosis.
However, we showed that protein vaccination selects locally effector TFH cells that become memory TFH cells and that remain in draining lymphoid tissue.
Long-term cellular depots of antigen in the form of peptid…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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