CORDIS Project
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The TFCoop project investigates how transcription factors work together to regulate gene expression. By analyzing the interactions of these factors across different cell types, the project aims to uncover the principles governing their cooperative behavior, which could enhance our understanding of cellular identity and…
Transcription Factors (TFs) are critical regulators of many essential cellular functions such as the acquisition of cell identities in healthy tissues and their dysregulation in disease.
Transcriptional activation of a gene typically requires the cooperative binding of multiple TFs, that subsequently recruit various additional cofactors.
Genomics has enabled the generation of a near-complete annotation of the cis-regulatory elements and TFs binding them across cell types.
Yet, the precise functi…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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