CORDIS Project
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The TF3C_EM project aims to elucidate the mechanism of transfer RNA gene transcription initiation by studying the binding of transcription factor IIIC to DNA. Using various biophysical techniques, the project will explore the structure and dynamics of this essential transcription factor.
Transfer RNAs (tRNAs) act as adaptor molecules, decoding messenger RNA and delivering the correct amino acid to the growing peptide chain.
Being instrumental in the cellular translation machinery, it is important to understand their synthesis mechanism.
In eukaryotes, tRNA gene (tDNA) transcription begins with transcription factor IIIC (TFIIIC) bound to 2 gene-internal promoter elements, A- and B-box.
This is followed by the recruitment of transcription factor IIIB and RNA polymerase III to form…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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